Introduction to bisphosphonate (PMIDA) Trade name: bisphosphonate Chemical name: N-(phosphonyl methyl) iminodiacetic acid Chemical properties: Bisphosphonate is a white loose powder, insoluble in water. English alias N-(Phosphonomethyl) iminodiacetic acid; PMIDA;  N-(phosphonomethyl)iminodiacetic acid hydrate

Quality index: white crystalline powder bisphosphine content,% ≥ 98.0 dry reduction,% ≤ 0.5 alkali insoluble substance,% ≤ 0.2 Use: mainly used as an intermediate of efficient, low toxicity, broad-spectrum herbicide glyphosate.

Bisphosphonate is a chemical product, pure and industrial products are white crystal, melting point 210℃(decomposition), slightly soluble in water, insoluble in ethanol, acetone, ether, benzene and other organic solvents. Can form salt with bases and amines.

The product is used as the main raw material for the production of broad-spectrum insecticidal post-bud herbicide. It is also an important intermediate of glyphosate in pesticide, medicine, rubber, electroplating and dye industries.

Preparation method Iminodiacetic acid sodium salt is added to excess hydrochloric acid to generate iminodiacetic acid hydrochloride, high temperature dehydration, then add phosphite and formaldehyde drops, after the drop, add liquid alkali, stir, crystallization. In the process of natural gas production of iminodiacetic acid, the intermediate product containing glycine, azotriacetic acid, chloroacetic acid, glycolic acid and ulotropine is used as raw material. Under the action of catalyst, it is added and condensed with phosphorus trichloride and paraformaldehyde to prepare the suspension of bisphosphonate crude product. The suspension is subjected to conventional crystallization, separation, washing and drying. That is to prepare the purity of more than 98% of the bisphosphonate products.

The characteristics of the preparation method are that bisphosphonate is synthesized from disodium iminodiacetic acid containing the above-mentioned impurities, without the complicated preparation and purification of iminodiacetic acid such as acidification, concentration, impurity removal, crystallization, separation, washing and drying of disodium iminodiacetate.